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Cenomed

General Information

Allograft bone biology and clinical applications

Allografts contain many chemical sites within their porous structure where progenitor cells and endothelial cells attach. They also contain growth factors within the bone matrix that are released as the graft is resorbed by osteoclasts. Allograft bone also contains bone morphogenetic protein, which has osteoinductive properties.

Demineralization increases the bioavailability of growth factors in the allograft bone matrix and also helps prevent transmission of HIV infection. Modern allograft bone-processing methods include advanced washing steps that reduce the number of residual cells in the graft. These washing steps also eliminate the risk of transmitting immunogenic antigens and viral diseases.

General Properties of Allografts

  • Lyophilized allografts can be stored at room temperature.
  • They show healing comparable to autografts and avoid the morbidity associated with autogenous bone harvesting.
  • They contain Bone Morphogenetic Protein (BMP) not found in synthetic or animal-derived grafts, and exhibit osteoinductive properties.
  • They provide sufficient graft volume in large bone losses where autograft is inadequate. Compared to autogenous cortical grafts, larger amounts and a wider range of sizes of allogenic cortical bone can be supplied.

Literature

  1. Comparison of bone regeneration using three demineralized freeze-dried bone allografts: A histological and histomorphometric study in rabbit calvaria
  2. A Comparison of Two Types of Decalcified Freeze-Dried Bone Allograft in Treatment of Dehiscence Defects around Implants in Dogs
  3. Determination of orthodontic tooth movement and tissue reaction following demineralized freeze-dried bone allograft grafting intervention
  4. Evaluation of Tissue Interaction and Orthodontic Tooth Movement Following Application of FDBA and DFDBA
  5. In vitro assay for osteoinductive activity of different demineralized freeze-dried bone allograft
  6. Opening wedge high tibial osteotomy using tibial wedge allograft: a case series study
  7. Save the Irremediable Tooth with Aid of Hydroxyapatite
  8. Histologische Untersuchungen zur Einheilung von Knochenersatzmaterialien
  9. Clinical, Histologic and Histomorphometric Evaluation of Bone Strip Allograft with Resorbable Membrane in Horizontal Alveolar Ridge Augmentation: A Preliminary Study